According to initial information, nine people have been killed when the police opened fire and one is critical. More than 65 people have been injured in the clashes between agitated protestors and police officials.
The injured people have been shifted to a nearby Government Hospital in the area.
The protest has been going on for months now and turned violent on Tuesday when protestors were not allowed to march up to the plant. Agitated protestors then started to pelt stones and toppled police vehicles.
The protestors also tried to gherao the collector's office and torched vehicles inside the premise.
Police officials resorted to lathicharge and tear gas to disperse the crowd to contain the tense situation.
Condemning the All India Anna Dravida Munnetra Kazhagam (AIADMK)-led State government for the unrest and the deaths, Kamal Hasaan's Makkal Needhi Maiam blamed the government for the unrest in the state.
The party in its statement said, "The peaceful protest by the people of Tuticorin against Sterlite, demanded justice was ignored by the Governments. Negligence of the Governments is the reason for all the unfortunate incidents. Citizens are not criminals. They are the ones who lose their lives, earlier due to Sterlite and now due to the Government's orders."
Actor Rajnikanth also took to Twitter and slammed the AIADMK.
He said, "Tamil Nadu Government's inaction is responsible for the violence in Tuticorin. Tamil Nadu Government should take the responsibility for the loss of life, and violence in Tuticorin."
Tuticorin witnessed several protests by locals and others against the Sterlite Copper plant and its proposed expansion. Protesters alleged that the plant was polluting groundwater in their area.